The Best Pharmacy POS Systems

Last updated on February 28, 2020

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pharmacy posA pharmacy point of sale system (POS) is crucial, whether you run a local drug store or a large retail chain pharmacy. Such a system should include features that will enhance sales and customer service, all while meeting regulatory needs.

The right POS system will allow you to manage your inventory with ease, and in turn provide your employees with more time to attend to their customers.

In choosing the best POS for your pharmacy, you should consider the tools provided, pricing, industry compliance, and ease of use. Here’s our list of the top-rated pharmacy POS systems.

The Top Pharmacy POS Systems 

Solid inventory management
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Fast searching for drugs and patients
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Multiple sessions on the same workstation
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Automated purchase order processing
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1. Best Overall Choice for Pharmacy POS: PioneerRx

With a mission objective of “Save + Revitalize Independent Pharmacy”, PioneerRx is geared towards independent pharmacies rather than big retail.

Still, the goal of this POS solution is to provide smaller operation businesses with innovative tools to outperform their larger competitors.

So, what features landed PioneerRx the ranking of most installed pharmacy software?

Inventory Management

With endless different types of medications, it is quite obvious that pharmacies require a robust inventory management system in place.

One of PioneerRx’s main features is its inventory management via shelf stickers. Instead of labeling the price of each item, this POS system generates shelf labels. This allows your employees to quickly see if an item needs to be restocked, or has been accidentally placed where it shouldn’t have been.

Additionally, if the price of the product changes, the system will automatically charge the customer the displayed shelf sticker price.

Other features within the PioneerRx inventory management system include usage-based ordering, auto reorder, and an intuitive recommended ordering.

Reporting and Financial Intelligence

PioneerRx is all about customizing and personalizing. This system has the ability to customize your search from the layout to grouping or filtering.

The PioneerRx system allows you to report prescription data to pharmaceutical manufacturers. Also, create your own label changes and financial reports.

Other prominent features include setting up customer auto pay, third party reconciliation, as well as competitive cash pricing analysis. Although other systems provide similar features, some don’t provide this level of reporting.

Security & Support

Without a doubt, PioneerRx has an outstanding pharmacy tech support team, available to assist with your needs throughout the day.

The data stored on the software is backed up on the server onsite, as well as on the mini Cloud within the system. The data is backed up automatically every 15 minutes, ensuring you will be up and running even in the event of a crash.

Moreover, this pharmacy software includes secure audited logins with biometrics capability. This goes a long way in ensuring that you are meeting industry and legal requirements.

Downside to PioneerRx POS

With a true commitment to innovation, PioneerRx has weekly updates. Some users have had trouble keeping up, and mentioned that more training should be included with such updates.

2. Most Efficiency Pharmacy POS System: PrimeRx

Perfect for independent, retail and multi-store owner pharmacies, this software provides a customized workflow that is efficient and simple.

From automated prescriptions fills, billing, and processing claims, PrimeRx is your all-in-one software solution.

Automated Refill Management System

This system can fill prescriptions by reviewing the patient, prescriber and medication inventory.

The Dashboard includes scheduled refills, as well as missed or expired refills.

Additionally, this system includes RxSync which allows you to sync all refills to a specific date. Prescriptions that have not been picked up by the customer will be flagged, returning them back to the inventory.

Customized Workflow Management

PrimeRx is your all-in-one system as it offers bills reconciliation, customized drug ordering from wholesalers, automatically updated cost of prescriptions, and automated backup of data.

As you can see, from inventory management to stay up to date with costs and bills, this system provides just about anything your pharmacy needs.

This software doesn’t come with any bells and whistles or high-end features. It is very straightforward and will be easy for your employees to use and navigate.

Customer Interaction and Updates

One noteworthy feature of PrimeRx is the Patient Status Board. Via this board, you can communicate with your customers as they wait for their prescriptions.

This allows customers to see where they are in the queue, and approximately how much longer they will have to wait. The customers won’t have to bother the pharmacist or tech and are not left in the dark.

Downside to PioneerRx POS

Some users have complained of the system freezing or being slow at times. It is likely that these users likely nee to upgrade the memory on their device.

It is important to note that PrimeRx has an excellent customer service and are all about constructive criticism. They address every comment or concern posted by users.

3. Best Up-and-Coming Pharmacy POS: BestRx

BestRx boasts a system that is rich in features at half of the cost of its competitors. With an opening line of “your search for the best pharmacy management software ends here”, this company is quite confident in its product.

With a system that’s straightforward and simple to use, as well as a name that is continuously growing, BestRx is the third choice on our list.

Document Management

Misplacing prescription or patient information is not only inconvenient, but it can actually lead to malpractice and legal issues. This is exactly why BestRx offers the perfect document management, by allowing your team to scan and import documents directly into the BestRx system.

Further, you can retrieve the documents at the touch of a button. The documents are backed up on an encrypted, HIPAA-compliant cloud server and are stored safely.

Electronic & Mobile Delivery Signature Capture

BestRx includes a signature pad where you can capture signatures electronically. This applies to prescription, HIPAA, and credit card signatures. The e-signatures are stored in the system and allow you to retrieve them when needed for audits or reporting.

BestRx also offers a mobile delivery system which allows the pharmacy to maintain digital records of all shipments received.

Patient Profile

With BestRx’s comprehensive patient profile, you will no longer have to wonder who’s who. Your employees will be able to refill, edit, transfer, and verify prescriptions directly from the patient’s profile.

Moreover, prescriptions that have expired or are due for a refill will be highly visible in the system, alerting both the pharmacist and tech. This interactive tool will be sure to leave a lasting impression on your customers.

Downside to BestRx POS

There are not any particular downsides we are aware of. Still, BestRx is still making its name and in the pharmacy industry and is not as widespread. It is excellent for startups but may not exactly serve large retail pharmacies’ needs.

4. Best Established Pharmacy POS: DataScan

With more than 35 years in business, DataScan knows a thing or two about the pharmacy business.

Not only is this company knowledgeable, it is innovative as it keeps up with industry changes.


DataScan not only values their clients’ feedback, the company also ensures that their clients truly understand the product.

That is, they offer training via documents, webinars, in person, and online. Whether you want someone to come to you or you would prefer to do it right from your computer, you’ll have access to training materials at all times.

Wholesaler Shopping & Sales Analysis

This software contains a system that can basically shop for you! It will find the best price for products across all wholesalers. Further, you can track a history of all results and sales history.

Financial Reporting & End of Day Reconciliation

Not only will the system keep track of your sales, it will also create financial reports for you and your accountant. In addition, you will have an end of day reconciliation statement to help you stay on track.

Downside to DataScan POS

Users have mentioned that they would like to see a more robust inventory system. This company is all about customer feedback and we can only predict this is something DataScan will certainly look into.

Pharmacy POS System Buyer’s Guide

Most pharmacy POS systems have inventory management and customer profiles, but you need to look for a POS system with features that will maximize your pharmacy’s sales and efficiency.

1. Image Scanning & Document Management

As mentioned earlier, document management is highly important for pharmacies. From prescriptions sent over from physicians to maintaining customers’ information in a database, there is a lot of information to track.

A POS system that offers a scanning feature will expedite and simply your workflow. With ease, the pharmacist can scan and store prescription images, as well as store insurance plan information.

2. Cloud Backup

Maintaining data is one thing, but making sure it is stored and will be accessible even in the event of a crash is just as important.

After all, scanning and storing information with ease will not matter if it can be lost just as easily. Therefore, a good retail POS system should include cloud backup that is easy to setup and will constantly backup the data.

3. Patient Medication Synchronization

Another helpful and innovative tool you should look for is the patient medication synchronization. With this feature, you will be able to ensure that a patient’s medication is filled at the same time of the month. This will promote medication adherence and in turn keep your customers satisfied.

4. Security

As a professional in the healthcare industry, you have access to customers’ personal information such as their social security number, date of birth, medical history, and driver’s license information.

Additionally, you have access to your customers’ credit card information when they fill their prescription.

In order to protect their medical and financial information, as well as protect your pharmacy from malpractice and legal action, you should ensure that you have a secure system and virus protection.

You should consider investing in a system with a sophisticated permissions system. Such a system will allow you to set up limited access to users, based on their role within their pharmacy.

5. Loyalty Program and Marketing

At the end of the day, a pharmacy is a business and it operates for profit. As such, you should look for a system with advanced targeted marketing. By using email and text options, you will be able to attract new clientele and keep previous ones coming back.

Further, consider a POS software with a comprehensive loyalty program. Using your customers’ emails and phone numbers, you can send promotions and manufacture coupons.

They’ll appreciate the savings and will be sure to come see you again when they’ll need their prescription filled!

6. Other Things to Consider

Ease of Use

With endless different types of prescriptions and complicated names, the last thing you would want to deal with is a cumbersome system.

Look for a POS system that is easy to learn, use, and navigate. A system that will keep your inventory updated, your customers’ information quickly accessible, and one that will keep everyone happy.


You certainly want the POS system you choose to have the necessary updates and upgrades, so you can keep up with current trends. Additionally, you want a system that is fast so you can service your customers’ in a timely manner.

Still, you should look for a software that provides continuous training. What good is a fast and innovative system if your staff can’t use it? A company that stands behind a commitment to training is highly important.

Our Final Verdict

When considering a POS system for your pharmacy, make sure it has the features your business needs. As we mentioned before, some of these features may be document management, cloud backup, patient medication synchronization, security, and more. Keep in mind that laws and legislation in the healthcare industry change often.

You should certainly look for a system that will keep up with regulatory and compliance. A POS system is more than a cash register. It is critical to your operations and profit and that is exactly why you need to invest in one that is easy to use but provides weekly updates.

All of the four pharmacy POS systems reviewed here offer free demos. Also, check out Paladin POS, another pharmacy POS system we did not review here in detail. Take advantage of each company’s demo to see its full software features. 

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